The potential use of novel chitosan-coated deformable liposomes in an ocular drug delivery system
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- 作者：Hongdan Chena ; 1 ; Hao Pana ; b ; 1 ; Panpan Lia ; Hui Wangc ; Xin Wanga ; Weisan Pana ; Yue Yuana ; hiyueyuan@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Deformable liposomes ; Penetration enhancement ; Pre-corneal retention ; Ocular tolerance ; Edge activator ; Gamma scintigraphy
- 刊名：Colloids and Surfaces B: Biointerfaces
- 出版年：2016
- 出版时间：1 July 2016
- 年：2016
- 卷：143
- 期：Complete
- 页码：455-462
- 全文大小：1478 K
文摘
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Deformable liposomes coated with chitosan (DL-CS) were developed.
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DL-CS could prolong pre-corneal retention and improve transcorneal penetration.
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Edge activator, Solutol HS-15, could potentiate the flexibility and penetrability.
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DL-CS could be a promising ocular drug delivery system.