Identification of amino acids in H9N2 influenza virus neuraminidase that are critical for the binding of two mouse monoclonal antibodies
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- 作者：Zhimin Wan ; Jianqiang Ye ; Jianjun Sang ; Hongxia Shao ; Kun Qian ; Wenjie Jin ; Aijian Qin ; aijian@yzu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Hongquan Wan ; hqwan129@yahoo.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：H9N2 virus ; Neuraminidase ; Escape mutant ; Amino acid
- 刊名：Veterinary Microbiology
- 出版年：2016
- 出版时间：1 May 2016
- 年：2016
- 卷：187
- 期：Complete
- 页码：58-63
- 全文大小：1184 K
文摘
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Generation and characterization of two mAbs binding different epitopes in the NA of a Eurasian H9N2 virus.
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Identify three critical amino acid positions in antigenic sites/epitopes in NA of H9N2 virus through characterizing the mAb escape mutants.
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Natural mutations at these three positions have occurred in the field.