Toll-like receptor 4 signaling is required for clusterin-induced tumor necrosis factor-α secretion in macrophage

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• 作者：Young-Jun Shim¹ ; Yoo-Keung Tae¹ ; Byeong-Ho Kang ; Jin-Sung Park ; Sol-Yi Jeon ; Bon-Hong Min ; ^{bhmin@korea.ac.kr}
• 关键词：Clusterin ; TLR4 ; TNF-α ; NF-κB ; Lipid raft ; Macrophage
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：22 January 2017
• 年：2017
• 卷：482
• 期：4
• 页码：1407-1412
• 全文大小：723 K
• 卷排序：482

文摘

Functional TLR4 is required for clusterin-induced TNF-α secretion. Clusterin increases NF-κB promoter activity via TLR4. The C-terminal domain of clusterin is important in activating TLR4 signal. Clusterin elicits TLR4 mobilization into lipid rafts of plasma membrane. Disruption of lipid rafts by MβCD abrogates clusterin-induced TNF-α and MMP-9.