Artesunate ameliorates severe acute pancreatitis (SAP) in rats by inhibiting expression of pro-inflammatory cytokines and Toll-like receptor 4
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- 作者：Yanyan Cena ; Chao Liua ; Xiaoli Lia ; Zifei Yana ; Mei Kuanga ; Yujie Sua ; Xichun Pana ; Rongxin Qina ; Xin Liub ; Jiang Zhengb ; Hong Zhoua ; zhouh64@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Severe acute pancreatitis ; Artesunate ; IL-6 ; IL-1β ; TLR4 ; NF-κB
- 刊名：International Immunopharmacology
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：38
- 期：Complete
- 页码：252-260
- 全文大小：2093 K
文摘
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Artesunate could increase survival of the severe acute pancreatitis model rats.
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This effect was related to suppression of digestive enzyme and pro-inflammatory cytokines.
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The mechanism may be related to inhibition the LPS-TLR4/NF-κB signaling pathway.
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Artesunate could be considered as a possible effective therapeutic agent for acute pancreatitis.