Possible role of PGD₂ in malaria infections

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• 作者：Pimwan Thongdee¹ ; Jiraporn Kuesap² ; Raewadee Wisedpanichkij³ ; Kesara Na-Bangchang¹ ; ⁴ ; ^{kesaratmu@yahoo.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Malaria ; Plasmodium vivax ; Plasmodium falciparum ; Prostaglandin D2 (PGD2) ; Malaria severity
• 刊名：Asian Pacific Journal of Tropical Medicine
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：9
• 期：9
• 页码：856-859
• 全文大小：268 K

文摘

To preliminarily investigate the possible role of prostaglandin D₂ (PGD₂) in malaria infections.

Methods

Blood and urinary samples (n = 120 each) were collected from Thai patients with Plasmodium falciparum (P. falciparum) with moderate (n = 26) and high (n = 4) parasitemia, patients with Plasmodium vivax (P. vivax) (n = 30), patients with fever associated with other infections (n = 30), and healthy subjects (n = 30). PGD₂ concentrations in plasma and urinary samples of healthy subjects, patients with fever associated with other infections and patients with malaria were determined using Prostaglandin D₂-MOX express EIA kit (Cayman Chemical, USA).

Results

The possible association between PGD₂ and malaria infections is clearly demonstrated with PGD₂ concentration in urine. The urinary PGD₂ concentrations were relatively high (about 5-fold) in patients with P. falciparum with moderate parasitemia and P. vivax infections compared with other groups. Furthermore, the concentration in patients with P. falciparum with moderate parasitemia and P. vivax infection were significantly higher than that in healthy subjects and patients with fever associated with other infections.

Conclusions

Urinary PGD₂ concentrations may offer a more dependable and useful tool for predicting malaria severity. Confirmation is this preliminary finding is required with a larger sample size.