¹H NMR-based metabolomics study of liver damage induced by ginkgolic acid (15:1) in mice

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• 作者：Lei Jiang ; Zhi-Hong Si ; Ming-Hui Li ; He Zhao ; Yong-Hong Fu ; Yue-Xiao Xing ; Wei Hong ; Ling-Yu Ruan ; Pu-Min Li ; Jun-Song Wang ; ^{wang.junsong@gmail.com}
• 关键词：Ginkgolic acid (15 ; 1) ; Mice ; NMR ; Metabolomics
• 刊名：Journal of Pharmaceutical and Biomedical Analysis
• 出版年：2017
• 出版时间：20 March 2017
• 年：2017
• 卷：136
• 期：Complete
• 页码：44-54
• 全文大小：2515 K
• 卷排序：136

文摘

The liver damage of GA (15:1) was studied by NMR-based metabolomics approach for the first time. The serum biochemical parameters were altered by GA (15:1) treatment in a dose-dependent manner. SUS plot showed common features of GA (15:1) dosing and dose-dependent metabolic changes. GA (15:1) induced disturbance in purine metabolism contributed to its antitumor and toxic effects.