Simvastatin attenuates macrophage-mediated gemcitabine resistance of pancreatic ductal adenocarcinoma by regulating the TGF-β1/Gfi-1 axis

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• 作者：Guozhe Xian^a ; ^b ; Juan Zhao^c ; Chengkun Qin^b ; Zhenhai Zhang^b ; Yanliang Lin^b ; Zhongxue Su^b ; ^{zhongxuesu@126.com}
• 关键词：Simvastatin ; Gemcitabine ; TGF-β1 ; Gfi-1 ; Tumor-associated macrophages ; Pancreatic ductal adenocarcinoma
• 刊名：Cancer Letters
• 出版年：2017
• 出版时间：28 January 2017
• 年：2017
• 卷：385
• 期：Complete
• 页码：65-74
• 全文大小：4523 K
• 卷排序：385

文摘

Simvastatin attenuated TAM-mediated gemcitabine resistance of PDAC cells. Exposure of PDAC cells to TAM-CM inhibited Gfi-1 expression. TAM-CM promoted the expression of CTGF and HMGB1 in PDAC cells. Simvastatin reversed the TAM-mediated signal response. Gfi-1 directly repressed the transcription of CTGF and HMGB1.