Bladder dysfunction changes from underactive to overactive after experimental traumatic brain injury

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• 作者：Hai-Hong Jiang^a ; ^b ; Olga N. Kokiko-Cochran^c ; Kevin Li^c ; Brian Balog^a ; Ching-Yi Lin^c ; ^d ; Margot S. Damaser^a ; ^b ; ^e ; Vernon Lin^d ; Julian Yaoan Cheng^f ; Yu-Shang Lee^c ; ^d ; ^{leey2@ccf.org}
• 关键词：Bladder ; Electromyogram ; Rat ; Traumatic brain injury ; Urethra ; Urodynamics
• 刊名：Experimental Neurology
• 出版年：2013
• 出版时间：February, 2013
• 年：2013
• 卷：240
• 期：Complete
• 页码：57-63
• 全文大小：1402 K

文摘

Although bladder dysfunction is common after traumatic brain injury (TBI), few studies have investigated resultant bladder changes and the detailed relationship between TBI and bladder dysfunction. The goal of this study was to characterize the effects of TBI on bladder function in an animal model. Fluid-percussion injury was used to create an animal model with moderate TBI. Female Sprague-Dawley rats underwent TBI, sham TBI or were not manipulated (na?ve). All rats underwent filling cystometry while bladder pressure and external urethral sphincter electromyograms were simultaneously recorded 1 day, 1 week, 2 weeks, and 1 month after injury. One day after injury, 70 % of the animals in the TBI group and 29 % of the animals in the sham TBI group showed no bursting activity during urination. Compared to na?ve rats, bladder function was mainly altered 1 day and 1 week after sham TBI, suggesting the craniotomy procedure affected bladder function mostly in a temporary manner. Compared to either na?ve or sham TBI, bladder weight was significantly increased 1 month after TBI and collagen in the bladder wall was increased. Bladder function in the TBI group went from atonic 1 day post-TBI to overactive 1 month post-TBI, suggesting that TBI significantly affected bladder function.