A genome-wide association study of mitochondrial DNA in Chinese men identifies two risk single nucleotide substitutions for idiopathic oligoasthenospermia
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- 作者：Chuncheng Lua ; b ; 1 ; Miaofei Xua ; b ; 1 ; Rong Wangc ; 1 ; Yufeng Qina ; b ; Jing Renc ; Wei Wua ; b ; Ling Songa ; b ; Shoulin Wanga ; b ; Zuomin Zhoua ; Hongbing Shena ; d ; Jiahao Shaa ; Zhibin Hua ; d ; Yankai Xiaa ; b ; Dengshun Miaoa ; c ; dengshun_miao@yahoo.com.cn" class="auth_mail" title="E-mail the corresponding author ; Xinru Wanga ; b ; xrwang@njmu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Oligoasthenospermia ; Mitochondrial DNA ; Genetic variant ; Haplogroup
- 刊名：Mitochondrion
- 出版年：2015
- 出版时间：September 2015
- 年：2015
- 卷：24
- 期：Complete
- 页码：87-92
- 全文大小：448 K
文摘
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Our study used NGS to sequence of complete human mtDNA genomes in blood cells.
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We found that the variants C16179T and A12361G were associated with increased risk of abnormal semen parameter.
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We studied the mtDNA haplogroup distribution of case and control groups, the genetic backgrounds may not affect our results.