Chitin-based fast responsive pH sensitive microspheres for controlled drug release

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• 作者：Yu Shang ; Fuyuan Ding ; Ling Xiao ; Hongbing Deng ; Yumin Du ; Xiaowen Shi
• 关键词：Chitin microsphere ; Ionically crosslinked ; Electrostatic droplet method ; pH sensitive ; Drug delivery
• 刊名：Carbohydrate Polymers
• 出版年：15 February, 2014
• 年：2014
• 卷：102
• 期：Complete
• 页码：413-418
• 全文大小：2200 K

文摘

Ionically crosslinked chitin microspheres were prepared by using electrostatic droplet method and the drug release from the microspheres was controlled by adjusting external pH. Specifically, chitin was dissolved in NaOH/urea solution at low temperature and functionalized with acrylamide moieties. Acrylamide-modified chitin microspheres with a diameter of 400-500 渭m can be obtained at the voltage of 6 kV and the pump speed of 5 mL h^鈭?. The formed microspheres were ionically crosslinked with Fe³⁺ and then complexed with polycationic polysaccharide chitosan. The structure of the microspheres was characterized by FT IR, SEM, and EDS analyses. Besides, the drug release behavior of the microspheres exhibited a fast responsive and pH sensitive release of vancomycin. It took 30 h for complete release of vancomycin in pH 4.0 buffer and pH 1.2 HCl solution while a fast release (10 min) occurred in pH 7.4 buffer. The results showed that the microspheres could be used in drug delivery.