Diversity of T_H cytokine profiles in patients with chronic rhinosinusitis: A multicenter study in Europe, Asia, and Oceania

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• 作者：Xiangdong Wang ; MD ; PhD^a ; ^&lowast ; ; Nan Zhang ; MD ; PhD^b ; ^&lowast ; ; Mingyu Bo ; MS^c ; ^&lowast ; ; Gabriele Holtappels^b ; Ming Zheng ; MD ; PhD^a ; Hongfei Lou ; MD ; PhD^a ; Hong Wang ; BS^a ; Luo Zhang ; MD ; PhD^a ; ^{dr.luozhang@139.com" class="auth_mail" title="E-mail the corresponding author} ; Claus Bachert ; MD ; PhD^b ; ^{claus.bachert@ugent.be" class="auth_mail" title="E-mail the corresponding author}
• 关键词：TH cytokines ; IgE ; ECP ; chronic rhinosinusitis ; phenotype ; endotype ; Europe ; Asia ; Australia
• 刊名：Journal of Allergy and Clinical Immunology
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：138
• 期：5
• 页码：1344-1353
• 全文大小：2022 K

文摘

To date, no study has evaluated the diversity of T_H cell cytokine patterns of patients with chronic rhinosinusitis (CRS) among centers in different continents using identical methods.

Objective

We sought to assess T_H cytokine profiles in patients with CRS from Europe, Asia, and Australia.

Methods

Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) and without nasal polyps (CRSsNP; n = 435) and control subjects (n = 138) were recruited from centers in Adelaide, Benelux, Berlin, Beijing, Chengdu, and Tochigi. Nasal mucosal concentrations of T_H2, T_H17, and T_H1 cytokines; eosinophilic cationic protein (ECP); myeloperoxidase (MPO); IL-8; and tissue total and Staphylococcus aureus enterotoxin (SE)–specific IgE were measured by using identical tools.

Results

Combinations of T_H1/T_H2/T_H17 cytokine profiles in patients with CRSwNP varied considerably between regions. CRSwNP tissues from patients from Benelux, Berlin, Adelaide, and Tochigi were T_H2 biased, whereas those from Beijing mainly demonstrated T_H2/T_H1/T_H17 mixed patterns, and patients from Chengdu showed an even lower T_H2 expression. Concentrations of IL-8 and tissue total IgE in patients with CRSwNP were significantly higher than those in control subjects in all regions. More than 50% of patients with CRSwNP in Benelux, Berlin, Adelaide, and Tochigi showed a predominantly eosinophilic endotype compared with less than 30% of patients in Beijing and Chengdu. SE-specific IgE was found in significantly greater numbers in patients with CRSwNP from Benelux, Adelaide, and Tochigi and significantly lower numbers in patients from Beijing and Chengdu. Moreover, the T_H1/T_H2/T_H17 cytokine profiles in patients with CRSsNP showed diversity among the 6 regions.

Conclusion

T_H cytokine levels, eosinophilic/neutrophilic patterns, and SE-specific IgE expressions show extreme diversity among patients with CRS from Europe, Asia, and Oceania.