Cinnamon extract improves fasting blood glucose and glycosylated hemoglobin level in Chinese patients with type 2 diabetes

详细信息    查看全文

• 作者：Ting Lu ; Hongguang Sheng ; Johnna Wu ; Yuan Cheng ; Jianming Zhu ; Yan Chen
• 关键词：ALT ; alanine aminotransferase ; AST ; aspartate aminotransferase ; FBG ; fasting blood glucose ; HbA1c ; glycosylated hemoglobin A1c ; HDL ; high-density lipoprotein ; LDL ; low-density lipoprotein
• 刊名：Nutrition Research
• 出版年：2012
• 出版时间：June, 2012
• 年：2012
• 卷：32
• 期：6
• 页码：408-412
• 全文大小：224 K

文摘

For thousands of years, cinnamon has been used as a traditional treatment in China. However, there are no studies to date that investigate whether cinnamon supplements are able to aid in the treatment of type 2 diabetes in Chinese subjects. We hypothesized cinnamon should be effective in improving blood glucose control in Chinese patients with type 2 diabetes. To address this hypothesis, we performed a randomized, double-blinded clinical study to analyze the effect of cinnamon extract on glycosylated hemoglobin A_1c and fasting blood glucose levels in Chinese patients with type 2 diabetes. A total of 66 patients with type 2 diabetes were recruited and randomly divided into 3 groups: placebo and low-dose and high-dose supplementation with cinnamon extract at 120 and 360 mg/d, respectively. Patients in all 3 groups took gliclazide during the entire 3 months of the study. Both hemoglobin A_1c and fasting blood glucose levels were significantly reduced in patients in the low- and high-dose groups, whereas they were not changed in the placebo group. The blood triglyceride levels were also significantly reduced in the low-dose group. The blood levels of total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and liver transaminase remained unchanged in the 3 groups. In conclusion, our study indicates that cinnamon supplementation is able to significantly improve blood glucose control in Chinese patients with type 2 diabetes.