Loss of BMP signaling through BMPR1A in osteoblasts leads to greater collagen cross-link maturation and material-level mechanical properties in mouse femoral trabecular compartments
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- 作者：Yanshuai Zhanga ; Erin Gatenby McNernyb ; Masahiko Terajimad ; Mekhala Raghavanc ; Genevieve Romanowicza ; Zhanpeng Zhanga ; Honghao Zhanga ; Nobuhiro Kamiyaa ; e ; g ; h ; Margaret Tantilloa ; Peizhi Zhuc ; Gregory J. Scottf ; Manas K. Rayf ; Michelle Lynchi ; Peter X. Maa ; Michael D. Morrisc ; Mitsuo Yamauchid ; David H. Kohna ; b ; Yuji Mishinaa ; e ; f ; mishina@umich.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：BMP receptor type 1A ; Collagen cross-links ; Cortical geometry ; Bone quality ; Biomechanical properties
- 刊名：Bone
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：88
- 期：Complete
- 页码：74-84
- 全文大小：1026 K
文摘
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Loss of BMPR1A in osteoblasts leads to more mature cross-links in collagen.
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Loss of BMPR1A leads to a greater mineral–matrix ratio in trabecular compartments.
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The hardness and elastic modulus were greater in the cKO trabecular compartments.
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Loss of BMPR1A affected cortical and trabecular compartments differently.
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Our results uncover novel aspects of BMP signaling on bone quality and bone mass.