Lentinan treatment led to a robust antidepressant-like effect in the tail suspension test and forced swim test after 60 min of treatment in mice.
Dectin-1, the receptor of lentinan, mediated the antidepressant-like effects of lentinan.
The prefrontal Dectin-1/AMPA receptor signaling pathway was essential for the robust antidepressant-like effects evoked by lentinan.