Fecal Microbiota Transplantation in Combination with Soluble Dietary Fiber for Treatment of Slow Transit Constipation: A Pilot Study

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• 作者：Xiaolong Ge^&lowast ; ; Hongliang Tian^&lowast ; ; Chao Ding ; Lili Gu ; Yao Wei ; Jianfeng Gong ; ^{jinlingh_gongjf@163.com" class="auth_mail" title="E-mail the corresponding author} ; Weiming Zhu ; Ning Li ; ^{jinlingh_lining@163.com" class="auth_mail" title="E-mail the corresponding author} ; Jieshou Li
• 关键词：Fecal microbiota transplantation ; Soluble dietary fiber ; Slow transit constipation ; Intestinal microbiota
• 刊名：Archives of Medical Research
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：47
• 期：3
• 页码：236-242
• 全文大小：199 K

文摘

Intestinal microbiota and soluble dietary fiber play an important role in intestinal microecology, which is closely related to gut motility. Regulating intestinal microecology comprised of fecal microbiota transplantation (FMT) or fiber supplementation is becoming a novel therapy for functional gastrointestinal disease. We launched this study to evaluate the efficacy and safety of FMT combined with fiber for slow transit constipation (STC).

Methods

We performed a study of 21 patients with STC. Participants received FMT (via nasojejunal tubes) on 3 consecutive days. After FMT, they were recommended to receive soluble dietary fiber for 4 weeks (8 g, twice daily). Rate of clinical improvement and remission, constipation-related symptoms (PAC-SYM scores), bowel movements per week, colonic transit time (CTT) and gastrointestinal quality-of-life index (GIQLI) were recorded during the 12-week follow-up.

Results

At the study end, clinical improvement and remission of constipated patients reached 66.7 and 42.9%, respectively. The patients showed an increased stool frequency from 1.7 ± 0.5 per week to 4.8 ± 2.1 per week (p <0.05) and an improved stool consistency after FMT combined with fiber. When compared to pre-treatment, PAC-SYM scores improved significantly from 2.0 ± 0.4 to 1.5 ± 0.6 after treatment (p <0.05). Meanwhile, patients showed an acceleration of colonic transit time from 81.9 ± 9.5 to 53.5 ± 11.2 h at week 12. During follow-up, patients felt satisfied with improved GIQLI. No serious adverse events were observed.

Conclusion

This is a pilot study confirming that FMT combined with fiber may improve symptoms experienced by constipated patients by regulating intestinal microecology, without any serious adverse events.