Differential modulation of expression of nuclear receptor mediated genes by tris(2-butoxyethyl) phosphate (TBOEP) on early life stages of zebrafish (Danio rerio)
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- 作者：Zhiyuan Maa ; 1 ; zhiyuan_nju@163.com" class="auth_mail" title="E-mail the corresponding author ; Yijun Yua ; 1 ; yjun.yu@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Song Tangb ; Hongling Liua ; hlliu@nju.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Guanyong Sua ; Yuwei Xiea ; John P. Giesya ; c ; d ; e ; Markus Heckerb ; c ; Hongxia Yua
- 关键词：Organophosphate ; Flame retardant ; Nuclear receptor ; Estrogen receptor ; Mineralocorticoid receptor ; Receptor-mediated network ; Endocrine disruption ; Toxicity
- 刊名：Aquatic Toxicology
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：169
- 期：Complete
- 页码：196-203
- 全文大小：1443 K
文摘
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Effects of TBOEP on expression of genes of several nuclear hormone receptors and their relationship with adverse effect pathways in zebrafish.
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TBOEP was neither an agonist nor antagonist of AR or AhR as determined by use of in vitro mammalian cell-based receptor transactivation assays.
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Modulation of ER- and MR-dependent pathways allowed for development of feasible receptor-mediated, critical mechanisms of toxic action.