Catechol-O-methyltransferase Val158Met polymorphism influences prefrontal executive function in early Parkinson's disease
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- 作者：Youwen Zhang ; Shujun Feng ; Kun Nie ; Xin Zhao ; Rong Gan ; Limin Wang ; Jiehao Zhao ; Hongmei Tang ; Liang Gao ; Ruiming Zhu ; Lijuan Wang ; wljgd68@163.com" class="auth_mail" title="E-mail the corresponding author ; Yuhu Zhang ; yhzhangsd@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Executive function ; Parkinson's disease ; COMT ; Polymorphism ; Prefrontal cortex
- 刊名：Journal of the Neurological Sciences
- 出版年：2016
- 出版时间：15 October 2016
- 年：2016
- 卷：369
- 期：Complete
- 页码：347-353
- 全文大小：305 K
文摘
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COMT Val158Met polymorphism is not associated with increased risk of PD in Chinese.
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The met/met PD patients performed worse on executive function compared with the val/val patients.
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COMT modulates executive function interacting with gender and dopaminergic medication.