Synthesis, structural characterization, in聽vitro cytotoxicities, DNA-binding and BSA interaction of diorganotin (IV) complexes derived from hydrazone Schiff base

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• 作者：Fei Wang ; Handong Yin ; ^{handongyin@163.com" class="auth_mail} ; Jichun Cui ; Yanwei Zhang ; Honglin Geng ; Min Hong ; ^{hongminlcu@163.com" class="auth_mail}
• 关键词：Diorganotin(IV) ; Hydrazone ; Crystal structure ; Cytotoxicity activity ; DNA-binding ; BSA-binding
• 刊名：Journal of Organometallic Chemistry
• 出版年：1 June, 2014
• 年：2014
• 卷：759
• 期：Complete
• 页码：83-91
• 全文大小：1317 K

文摘

Five diorganotin(IV) complexes of benzoylformic acid 3-hydroxy-2-naphthoyl hydrazone, [R₂SnLY]₂ (L聽=聽3-HO-C₁₀H₆CON₂C(C₆H₅)CO₂) with Y = H₂O, R聽=聽CH₃ (class="boldFont">1), Y聽=聽EtOH, R聽=聽Ph (class="boldFont">3), Y聽=聽EtOH, R聽=聽o-Cl-Bz (class="boldFont">4), Y聽=聽EtOH, R聽=聽o-F-Bz (class="boldFont">5), and [R₂SnLY] with Y聽=聽EtOH, R聽=聽n-Bu (class="boldFont">2) were prepared, which were structurally characterized by X-ray crystallography, elemental, IR and NMR (¹H and ¹³C ) spectroscopy. Structural analysis reveal that the ligand presents as tridentate ligand with ONO donors and coordinates to the tin center in an enolic form. Compound class="boldFont">2 is a monomer while the other compounds are weakly bridged dimers with weak Sn鈰疧 interactions. In聽vitro cytotoxicities of compounds class="boldFont">1, class="boldFont">3 and the ligand were determined to explore their potential anticancer activities. DNA-binding properties of class="boldFont">1 and class="boldFont">3 with calf thymus DNA (ct-DNA) were investigated by fluorescence quenching method with ethidium bromide (abbr. EB)-DNA system. Furthermore, the protein fluorescence quenching studies reveal that there are strong binding interactions between compounds class="boldFont">1, class="boldFont">3 and bovine serum albumins (BSA). Synchronous fluorescence spectra show that both the tryptophan and tyrosine residues in BSA are affected by the two compounds.