Autophagy ameliorates cognitive impairment through activation of PVT1 and apoptosis in diabetes mice
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- 作者：Zhigui Li ; Shuang Hao ; Hongqiang Yin ; Jing Gao ; Zhuo Yang ; zhuoyang@nankai.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：PVT1 ; plasmacytoma variant translocation 1 ; lncRNA ; long noncoding RNA ; STZ ; streptozotocin ; 3-MA ; 3-methyladenine ; LTP ; long term potentiation ; DPT ; depotentiation ; PPF ; pair-pulse facilitation ; miRNA ; microRNA ; mRNA ; messenger RNA ; qPCR ; real-time quantitative PCR ; cDNA ; complementary DNA ; PI ; propidium iodide ; PBS ; phosphate-buffered saline
- 刊名：Behavioural Brain Research
- 出版年：2016
- 出版时间：15 May 2016
- 年：2016
- 卷：305
- 期：Complete
- 页码：265-277
- 全文大小：2991 K
文摘
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Autophagic inhibition exacerbated cognitive impairment in diabetic mice.
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Autophagic inhibition exacerbated dysfunction of synaptic plasticity in diabetic mice.
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PVT1 mediated autophagy induced apoptosis but not necrosis in diabetic mice.