PTD-fused p53 as a potential antiviral agent directly suppresses HBV transcription and expression
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- 作者：Xiaoyu Chua ; b ; Bo Wua ; b ; Hongxia Fana ; Junwei Houa ; Junli Haoa ; Jun Hua ; Baozhong Wanga ; b ; Guangze Liuc ; lgze68@163.com" class="auth_mail" title="E-mail the corresponding author ; Changfei Lia ; lichangfei2006@163.com" class="auth_mail" title="E-mail the corresponding author ; Songdong Menga ; mengsd@im.ac.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：PTD ; p53 ; Antiviral ; HBV
- 刊名：Antiviral Research
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：127
- 期：Complete
- 页码：41-49
- 全文大小：1628 K
文摘
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PTD mediates p53 internalization into hepatocytes.
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PTD-p53 targets HBV enhancers.
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PTD-p53 directly inhibits viral mRNAs and antigen production.
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PTD-p53 effectively reverses HBV-mediated autoregulatory feedback loop of viral transcription.