MicroRNAs in oral lichen planus and potential miRNA-mRNA pathogenesis with essential cytokines: a review

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• 作者：Hui Ma ; MD ; DDS ; Yuanqin Wu ; MD ; DDS ; Huamei Yang ; MD ; DDS ; Jiajia Liu ; MD ; DDS ; Hongxia Dan ; PhD ; DDS ; Xin Zeng ; PhD ; DDS ; Yu Zhou ; PhD ; DDS ; ^{Zhouyu19830306@sina.com" class="auth_mail" title="E-mail the corresponding author} ; Lu Jiang ; PhD ; DDS ; ^{jianglu@scu.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Qianming Chen ; PhD ; DDS
• 刊名：Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：122
• 期：2
• 页码：164-173
• 全文大小：305 K

文摘

Oral lichen planus (OLP) is a potentially premalignant condition with unknown pathogenesis. Immune and inflammatory factors are thought to play important roles in the development of OLP, and cytokines, such as interferon (IFN)-γ and tumor necrosis factor (TNF)-α, can act as critical players in the immunopathogenesis of OLP. MicroRNAs (miRNAs) are closely correlated with cytokines in various inflammation-related diseases. In patients with OLP, miRNA-146a and miRNA-155 are increased in peripheral blood mononuclear cells, and numerous miRNAs have been shown to exhibit altered expression profiles in lesions. Although the microRNA–messenger RNA (miRNA–mRNA) network is thought to be involved in the development of OLP, in-depth studies are lacking. Here, we summarize current data on the mechanisms of action of miRNAs regulating typical cytokines in OLP, including interleukin (IL)-10, IL-17, IL-22, IFN-γ, and TNF-α, to study the genetic basis of the pathogenesis of OLP and to provide prospects of therapy.