Metabolomics study on the antitumor effect of marine natural compound flexibilide in HCT-116 colon cancer cell line
详细信息 查看全文
- 作者：Dan Gaob ; c ; 1 ; Yini Wanga ; c ; 1 ; Weiyi Xiea ; c ; Ti Yanga ; c ; Yuyang Jiangb ; d ; Yuewei Guoe ; Jin Guanf ; guanj0418@163.com" class="auth_mail" title="E-mail the corresponding author ; Hongxia Liub ; c ; liuhx@sz.tsinghua.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Metabolomics ; UPLC/Q-TOF MS ; Flexibilide ; HCT-116 cells ; Action mechanism
- 刊名：Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences
- 出版年：2016
- 出版时间：1 March 2016
- 年：2016
- 卷：1014
- 期：Complete
- 页码：17-23
- 全文大小：1025 K
文摘
- •
For the first time, we employed an UPLC/Q-TOF MS based metabolomic technique to investigate the drug action mechanism of marine natural compound flexibilide.
- •
18 distinct metabolites involved in five metabolic pathways in HCT-116 cells were found to be disturbed by flexibilide.
- •
Two possible action mechanisms of flexibilide were proposed by analysis of the disturbed pathways and metabolites.
- •
The metabolomic approach provides potential in further improvement and application of flexibilide and its derivatives.