Effect of 5-aminolevulinic acid photodynamic therapy on Candida albicans biofilms: An in vitro study
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- 作者：Hang Shia ; 1 ; shihang1016@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Jiyang Lib ; 1 ; lijiyang@fudan.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Hui Zhanga ; huihui_8507@163.com" class="auth_mail" title="E-mail the corresponding author ; Jie Zhanga ; fdhszhangjie@163.com" class="auth_mail" title="E-mail the corresponding author ; Hongying Suna ; huashan110926@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Antifungal therapy ; 5-Aminolevulinic acid ; Biofilm ; Candida albicans ; Photodynamic therapy
- 刊名：Photodiagnosis and Photodynamic Therapy
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：15
- 期：Complete
- 页码：40-45
- 全文大小：2361 K
文摘
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Photodynamic therapy has shown great promise for the inactivation of Candida species. However, the effectiveness of ALA-PDT against biofilm-associated Candida albicans remains poorly documented.
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Our study revealed for the first time that protoporphyrin IX (PpIX), the real photosensitizer can be absorbed in biofilm-grown C.albicans.
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Our results showed that under appropriate parameters, photochemistry can be triggered by light in combination with ALA and eliminates Candida albicans effectively.