- 作者：Sanjiv B. Amin ; Mark Orl ; o ; Hongyue Wang
- 关键词：ABR ; Auditory brainstem evoked response ; GA ; Gestational age
- 刊名：The Journal of Pediatrics
- 出版年：November, 2013
- 年：2013
- 卷：163
- 期：5
- 页码：1267-1271
- 全文大小：141 K
Objective
To determine whether cord serum ferritin level is associated with auditory brainstem evoked response聽interpeak latencies, an index of auditory neural myelination, in infants at 鈮?5 weeks gestational age (GA).Study design
This prospective study compared auditory neural myelination in infants with latent iron deficiency (cord serum ferritin, 11-75 ng/mL) and infants with normal iron status (cord serum ferritin, >75 ng/mL) at birth. Our inclusion criteria were infants born at 鈮?5 weeks GA who had cord blood collected soon after birth and had 1 or more of the following risk factors for poor in utero iron status: maternal diabetes mellitus, pregnancy-induced hypertension, and intrauterine growth restriction. Cord serum ferritin level was measured using the chemiluminescence immunoassay method. Auditory brainstem evoked response was measured using 80-dB normal hearing level click stimuli at a rate of 69.9/second within 48 hours after birth to evaluate interpeak latencies, a measure of nerve conduction velocity or myelination.
Results
Of the 45 infants studied, 12 had latent iron deficiency. On repeated-measures ANCOVA using interpeak latencies I-III, III-V, and I-V as multiple outcomes, infants with latent iron deficiency had significantly prolonged interpeak latencies (P = .01) compared with infants with normal iron status after controlling for confounders.
Conclusion
In utero latent iron deficiency is associated with abnormal auditory neural myelination at birth in infants born at 鈮?5 weeks GA.