Lithium lengthens circadian period of cultured brain slices in area specific manner
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- 作者：Tomoko Yoshikawa1 ; Sato Honma ; sathonma@med.hokudai.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：BD ; bipolar disorder ; SCN ; suprachiasmatic nucleus ; MAP ; methamphetamine ; MAO ; methamphetamine induced circadian oscillator ; DD ; constant dark ; OB ; olfactory bulb ; ME ; median eminence ; SN ; substantia nigra ; 3β ; glycogen synthase kinase ; 3β ; GSK
- 刊名：Behavioural Brain Research
- 出版年：2016
- 出版时间：1 November 2016
- 年：2016
- 卷：314
- 期：Complete
- 页码：30-37
- 全文大小：2045 K
文摘
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Lithium lengthens the circadian periods in the SCN, olfactory bulb, median eminence and substantia nigra with dose and area specific manner.
The effective dose of lithium was much higher than the plasma levels that are required for lengthening the circadian behavior rhythms as well for therapeutic use.
Low dose of lithium did not lengthened the period but enhanced the amplitude of circadian rhythms, which may exert therapeutic effects on BD.