Deconstructing Circadian Rhythmicity with Models and Manipulations

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• 作者：Scott D. Pauls¹ ; Ken-Ichi Honma² ; Sato Honma² ; Rae Silver³ ; ⁴ ; ⁵ ; ^{Rae.Silver@columbia.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：suprachiasmatic nucleus ; clock genes ; neural circuits ; connectome ; multiplex models ; coupling
• 刊名：Trends in Neurosciences
• 出版年：2016
• 出版时间：June 2016
• 年：2016
• 卷：39
• 期：6
• 页码：405-419
• 全文大小：2695 K

文摘

A master brain clock, localized to the hypothalamic suprachiasmatic nucleus (SCN), coordinates daily rhythms of physiology and behavior. Within the SCN, interconnected individual neurons are oscillators that, as an ensemble, function to send a coherent timing signal to the brain and body. However, individually, these neurons display different amplitudes, periods, and phases of oscillation. The dynamic properties of the SCN have been characterized over several spatial levels of analysis, from proteins to cells to tissues, and over several temporal ranges, from milliseconds to weeks. Modeling tools guide empirical research in this complex and multiscale spatiotemporal environment. Given that the SCN is a prototypical example of oscillating neural systems, principles of its organization hold promise as general prototypes of rhythms in other frequencies.