- 作者：Bianca Weinstock-Guttman ; Dana Horakova ; Robert Zivadinov ; Miriam Tama?o-Blanco ; Darlene Badgett ; Michaela Tyblova ; Manuela Vaneckova ; Zdenek Seidl ; Jan Krasensky ; Niels Bergsl ; Deepa P. Ramasamy ; Jesper Hagemeier ; Eva Havrdova ; Murali Ramanathan
- 关键词：Lipid ; Cholesterol ; Epstein&ndash ; Barr virus ; Environmental factor interactions ; Multiple sclerosis ; Clinically isolated syndromes
- 刊名：Journal of Neuroimmunology
- 出版年：2013
- 出版时间：15 October, 2013
- 年：2013
- 卷：263
- 期：1-2
- 页码：121-127
- 全文大小：543 K
Objectives
To investigate whether anti-herpesvirus antibodies are associated with serum cholesterol profiles in clinically isolated syndromes (CIS).Methods
Pre-treatment serum samples from 118 high-risk CIS patients were analyzed for IgG antibodies against cytomegalovirus (anti-CMV), Epstein Barr virus (EBV) viral capsid antigen (VCA) and EBV nuclear antigen-1 (EBNA-1). A lipid profile consisting of high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and total cholesterol (TC) was obtained. Clinical and MRI assessments were obtained at baseline, 6, 12, and 24 months after start of interferon-beta treatment.
Results
The study included 118 CIS patients (77 females, 41 males, 65.3 % female; mean age: 28.1 ¡À SD 8.1 years). Anti-EBV EBNA-1 antibody levels were associated with LDL-C (p = 0.009) and TC (p = 0.008) levels. Anti-CMV positivity status was associated with reduced time to relapse (p = 0.006) and the greater number of relapses (p = 0.009) in patients with high HDL-C. Anti-EBV VCA antibody levels were associated with greater number of new T2 lesions (p = 0.002) and with increased brain atrophy (p < 0.001) in patients with high LDL-C.
Conclusions
Our results indicate that higher levels of anti-EBV EBNA-1 antibodies are associated with higher LDL-C and TC levels. Anti-CMV positive individuals have greater disease progression in the presence of higher HDL-C levels. Individuals with higher levels of anti-EBV VCA antibodies have greater progression on MRI measures in the presence of higher LDL-C.