The effect of reduced physical activity on longevity of mice

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• 作者：Mlekusch ; Walter ; Tillian ; Hilmar ; Lamprecht ; Manfred ; Trutnovsky ; Helmut ; Horejsi ; Renate ; et. al.
• 关键词：Female mice ; Mobility restriction ; Longevity
• 刊名：Mechanisms of Ageing and Development
• 出版年：1996
• 出版时间：July 17, 1996
• 年：1996
• 卷：88
• 期：3
• 页码：159-168
• 全文大小：534 K

文摘

Reduced physical activity leads, in female mice, to a reduction of the average and maximal life span. The average age at death of the inactive experimental group was 497 ± 121 days (mean ± S.D.) compared to 557 ± 139 days in the active control group, and the six oldest inactive experimental mice died at age 732 ± 50 days, while the six oldest active control mice died at 890 ± 52 days. The restriction of mobility was connected with a higher growth rate and a higher body weight in spite of a significant decrease in food intake. In spite of a reduced food intake leading to a reduced whole body metabolism, the results show that mobility restriction shortens life span in female mice.