DNA Microarray Analysis of the Effect on Inflammation in Patients Treated with Acupuncture for Allergic Rhinitis

详细信息    查看全文

• 作者：Horng-Sheng Shiue ; M.D. ; M.Sc. ; Yun-Shien Lee ; Ph.D. ; Chi-Neu Tsai ; Ph.D. ; Yu-Mei Hsueh ; Ph.D. ; Joen-Rong Sheu ; Ph.D. ; Hen-Hong Chang ; M.D.
• 刊名：Deutsche Zeitschrift f¨¹r Akupunktur
• 出版年：2008
• 出版时间：2008
• 年：2008
• 卷：51
• 期：4
• 页码：53-54
• 全文大小：68 K

文摘

Background

Allergic rhinitis affects approximately 30 % of adults and up to 40 % of children in industrialized societies. Medicines available for relief of allergic rhinitis symptoms include antihistamines, decongestants, leukotriene inhibitors, topical hormones, and corticosteroids. However, the negative side-effects of antiallergic medicines cause many patients with allergic rhinitis to choose traditional Chinese medical treatments, such as taking Chinese herbs or treatment with acupuncture.

Objectives

This study assessed the effect of acupuncture for treatment of allergic rhinitis.

Methods

Eighteen (18) patients with allergic rhinitis were treated with acupuncture 8 times over a 4-week period, and peripheral blood of these patients was collected at each visit for analysis of gene expression via cDNA microarray. To estimate the therapeutic effect of acupuncture objectively, patients completed the rhinoconjunctivitis quality of life questionnaire (RQLQ) before and after acupuncture therapy.

Results

Based upon patients' response to the RQLQ, acupuncture therapy significantly reduced allergic rhinitis symptoms, including nasal symptoms, non-hay fever symptoms, and sleep and practical problems (associated with daily activities). In addition, expression of interleukin-1 receptor-¦Á (IL1R1) in peripheral blood was significantly decreased at 2 hours, 24 hours, and 4 weeks after acupuncture treatment in these patients.

Conclusions

To our knowledge, this is the first report of cDNA microarray analysis of differential gene expression the peripheral blood of patients with allergic rhinitis before and after acupuncture treatment. Out data suggest that the balance between T-helper 1 and T-helper 2 cell-derived proinflammatory versus anti-inflammatory cytokines might be improved by acupuncture treatment.