Polycyclic xanthones via pH-switched biotransformation of α-mangostin catalysed by horseradish peroxidase exhibited cytotoxicity against hepatoblastoma cells in vitro
Six xanthone analogues (1–6) were obtained in an environmental friendly way. Compound 1 with a peroxide group exhibited potent cytotoxic activity. Compound 1 induced G2/M arrest and activated caspase-dependent apoptotic pathway. Compound 1 inhibited the ROS-mediated and MAPK signalling pathway.