Papillary squamous cell carcinoma of the head and neck: a clinicopathologic series

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• 作者：Jonathon O.  ; Russell MD^a ;   ; ^c ; Aaron P.  ; Hoschar MD^b ; Joseph  ; Scharpf MD^c ;   ; ^{scharpj@ccf.org}
• 刊名：American Journal of Otolaryngology
• 出版年：2011
• 出版时间：November-December 2011
• 年：2011
• 卷：32
• 期：6
• 页码：557-563
• 全文大小：933 K

文摘

Purpose

Papillary squamous cell carcinoma (PSCC) is a rare malignancy that has been associated with human papillomavirus. We present all cases of this disease at a single academic teaching hospital over the last 30 years.

Materials and Methods

A retrospective chart review was performed for all patients with a diagnosis of PSCC. Of 65 patients identified, 52 were included after meeting established diagnostic criteria. Chart reviews were performed for patient demographics, overall survival, and disease-free survival.

Results

Mean age at diagnosis was 65 years, with a male to female ratio of 2.3:1. The majority of lesions (n = 34, 65.4 % ) arose in areas commonly affected by benign squamous papillomas, with the laryngopharynx the most commonly affected (n = 19, 36.5 % ), followed by the oral cavity (n = 18, 34.6 % ), sinonasal tract (n = 8, 15.4 % ), and oropharynx (n = 7, 13.5 % ). Two- and 5-year disease-free survival rate was 68 % and 46 % , respectively. Overall survival rate was 90 % and 72 % at 2 and 5 years, respectively.

Conclusions

Papillary squamous cell carcinoma of the head and neck is a distinct variant of conventional squamous cell carcinoma with a good prognosis despite high locoregional recurrence rates. Histology and subsite localization corroborate existing evidence that human papillomavirus may be involved.