KRAS-MEK Signaling Controls Ago2 Sorting into Exosomes
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- 作者：Andrew J. McKenzie1 ; 8 ; Daisuke Hoshino2 ; Nan Hyung Hong1 ; Diana J. Cha3 ; Jeffrey L. Franklin4 ; 5 ; 6 ; Robert J. Coffey4 ; 5 ; 6 ; James G. Patton3 ; Alissa M. Weaver1 ; 5 ; 7 ; alissa.weaver@vanderbilt.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：exosomes ; extracellular vesicles ; miRNA ; Argonaute ; extracellular RNA ; signaling
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：3 May 2016
- 年：2016
- 卷：15
- 期：5
- 页码：978-987
- 全文大小：4267 K
文摘
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Active KRAS suppresses Ago2 interaction with endosomes and secretion into exosomes
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KRAS-MEK-ERK signaling promotes Ago2 phosphorylation on serine 387
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S387 phosphorylation inhibits Ago2-endosome association and sorting to exosomes
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Ago2 levels and phosphorylation control secretion of candidate miRNAs in exosomes