Longitudinal analysis of cytokine expression during neoadjuvant chemoradiotherapy and subsequent surgery in esophageal cancer patients

详细信息    查看全文

• 作者：Dirk J. Bosch ; M.D. ; Ph.D.^a ; Da Wang ; M.Sc.^a ; Maarten W.N. Nijsten ; M.D. ; Ph.D.^b ; V&eacute ; ronique E.M. Mul ; M.D.^c ; Geke A.P. Hospers ; M.D. ; Ph.D.^d ; Johannes G.M. Burgerhof ; M.Sc.^e ; Michel M.R.F. Struys ; M.D. ; Ph.D.^f ; John Th.M. Plukker ; M.D. ; Ph.D.^a ; ^{j.t.m.plukker@umcg.nl" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Esophagectomy ; Cytokine ; Neoadjuvant chemoradiotherapy
• 刊名：The American Journal of Surgery
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：212
• 期：1
• 页码：89-95
• 全文大小：496 K

文摘

The purpose of this study was to provide more insight in the course of cytokine concentrations related to pathologic response (pR) and complications after neoadjuvant chemoradiotherapy (NCRT) and esophagectomy in esophageal cancer patients.

absSec_2">Methods

abspara0015">Patients treated with NCRT followed by transthoracic esophagectomy (n = 35) or transthoracic esophagectomy alone (n = 8) were included. Eight different cytokine concentrations were determined during NCRT, esophagectomy, and the first postoperative week.

absSec_3">Results

abspara0020">Platelet-activating factor before NCRT was associated with pR (P = .011) and remained elevated in patients with a better response. Concentrations of intestinal fatty acid–binding protein and angiopoietin 1 (Ang-1) were different between patients with and without NCRT. Decreased concentrations of Ang-1 on the third postoperative day were associated with postoperative complications (P = .046).

absSec_4">Conclusions

abspara0025">In this observational study, elevated platelet-activating factor concentrations before NCRT were associated with pR. NCRT is associated with decreased Ang-1 concentrations, whereas reduced Ang-1 concentrations were associated with postoperative complications.