Human hemoglobin structural and functional alterations and heme degradation upon interaction with benzene: A spectroscopic study
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- 作者：Reza Hosseinzadeha ; b ; Ali Akbar Moosavi-Movahedia ; c ; moosavi@ut.ac.ir" class="auth_mail" title="E-mail the corresponding author
- 关键词：Hemolysis ; Heme destruction ; Benzene interaction ; Synchronous fluorescence ; Hemoglobinemia ; Hemoglobin species
- 刊名：Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
- 出版年：2016
- 出版时间：15 March 2016
- 年：2016
- 卷：157
- 期：Complete
- 页码：41-49
- 全文大小：1048 K
文摘
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The effect of benzene on hemoglobin structure and stability and heme prosthetic group integrity was studied.
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Benzene has high hemolytic potential and altered both the globin and heme of hemoglobin and caused increasing met- and deoxy-Hb and decreasing oxy-Hb also oxygen affinity was decreased strongly.
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Results showed that benzene has a high potential for penetrating the hydrophobic pocket of hemoglobin.
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CWSFS results indicated that at least five heme-degraded species were produced.