Heparin-induced thrombocytopenia: a common complication in cardiac transplant recipients

详细信息    查看全文

• 作者：Hourigan ; Lisa A. ; Walters ; Darren L. ; Keck ; Sally A. ; Dec ; G.William
• 刊名：The Journal of Heart and Lung Transplantation
• 出版年：2002
• 出版时间：December, 2002
• 年：2002
• 卷：21
• 期：12
• 页码：1283-1289
• 全文大小：221 K

文摘

Heparin-induced thrombocytopenia (HIT) is an idiosyncratic complication of heparin therapy triggered by the development of immunoglobulin G (IgG) antibodies to platelet factor 4 heparin. It typically results in a 50 % decrease in platelet count. Paradoxically, although bleeding is rare, there is a high risk of venous or arterial thrombotic events. Given that many patients awaiting transplantation are exposed to heparin for prolonged periods, we sought to determine the frequency of HIT and its consequences among patients before and after cardiac transplantation.