Normalization of Left Ventricular Ejection Fraction and Incidence of Appropriate Antitachycardia Therapy in Patients With Implantable Cardioverter Defibrillator for Primary Prevention of Sudden Death
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- 作者：Chad M. House ; BS ; RDCS1 ; 2 ; Danny Nguyen ; BS3 ; Avis J. Thomas ; MS ; FSA4 ; William B. Nelson ; MD ; PhD ; FACC1 ; 2 ; 5 ; Dennis W. Zhu ; MD ; FHRS ; FACC1 ; 2 ; 5 ; dennis.w.zhu@healthpartners.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Left ventricular ejection fraction ; implantable cardioverter-defibrillator ; cardiac resynchronization therapy&ndash ; defibrillator ; sudden cardiac death ; primary prevention ; generator replacement
- 刊名：Journal of Cardiac Failure
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：22
- 期：2
- 页码：125-132
- 全文大小：861 K
文摘
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Fifty-five (44%) of the 125 patients who received ICDs or CRT-Ds for primary prevention of sudden death and never received appropriate antitachycardia therapy had partially improved (36%–49%) or normalized (≥50%) LVEF at the time of generator replacement.
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During an overall follow-up of 25 ± 18 months after replacement, none of the 30 patients with normalized LVEF experienced a major ventricular tachyarrhythmic event, whereas 20% of the patients with partially improved LVEF required appropriate antitachycardia therapy.
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Although generator replacement is necessary in patients with partially improved LVEF, these data suggest that patients whose LVEF normalizes over time may be at a lower risk for appropriate antitachycardia therapy.