Non-oncogenic Acute Viral Infections Disrupt Anti-cancer Responses and Lead to Accelerated Cancer-Specific Host Death
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- 作者：Frederick J. Kohlhapp1 ; 2 ; 11 ; Erica J. Huelsmann3 ; 11 ; Andrew T. Lacek3 ; 11 ; Jason M. Schenkel4 ; 11 ; Jevgenijs Lusciks3 ; 5 ; Joseph R. Broucek6 ; Josef W. Goldufsky3 ; Tasha Hughes6 ; Janet P. Zayas3 ; Hubert Dolubizno3 ; Ryan T. Sowell3 ; Regina Kü ; hner3 ; Sarah Burd7 ; John C. Kubasiak6 ; Arman Nabatiyan3 ; 5 ; Sh&rsquo ; Rae Marshall1 ; Praveen K. Bommareddy1 ; Shengguo Li1 ; Jenna H. Newman1 ; Claude E. Monken1 ; 2 ; Sasha H. Shafikhani3 ; Amanda L. Marzo3 ; 5 ; Jose A. Guevara-Patino8 ; Ahmed Lasfar1 ; 9 ; Paul G. Thomas10 ; Edmund C. Lattime1 ; 2 ; Howard L. Kaufman1 ; 2 ; Andrew Zloza1 ; 2 ; 12 ; andrew.zloza@rutgers.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：cancer ; infection ; concomitant ; melanoma ; breast cancer ; influenza ; mouse ; PD-1 ; CD8+ T cells ; viral
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：18 October 2016
- 年：2016
- 卷：17
- 期：4
- 页码：957-965
- 全文大小：2774 K
文摘
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Non-oncogenic infections promote distal tumor growth and cancer-specific death
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Infection shunts anti-tumor CD8+ T cells to the site of infection
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Anti-tumor CD8+ T cells express high levels of PD-1 at the infection site
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PD-1 blockade reverses anti-tumor CD8+ T cell loss from the tumor and tumor growth