Hoxb1 regulates proliferation and differentiation of second heart field progenitors in pharyngeal mesoderm and genetically interacts with Hoxa1 during cardiac outflow tract development
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- 作者：Marine Rouxa ; b ; 1 ; Brigitte Laforesta ; b ; Mario Capecchic ; Nicolas Bertranda ; b ; 2 ; Sté ; phane Zaffrana ; b ; stephane.zaffran@univ-amu.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Heart ; Mouse ; Hox genes ; Second heart field ; Congenital heart defect
- 刊名：Developmental Biology
- 出版年：2015
- 出版时间：15 October 2015
- 年：2015
- 卷：406
- 期：2
- 页码：247-258
- 全文大小：13486 K
文摘
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Mutants for Hoxb1 have outflow tract defects.
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FGF/ERK and BMP/SMAD signaling are deregulated in Hoxb1 mutant embryos.
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Premature differentiation of second heart field progenitors in the pharyngeal mesoderm of Hoxb1 deficient embryos.
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Redundant roles of Hoxa1 and Hoxb1 during outflow tract development.