Structural and functional biology of arachidonic acid 15-lipoxygenase-1 (ALOX15)
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- 作者：Igor Ivanov ; Hartmut Kuhn ; hartmut.kuehn@charite.de" class="auth_mail" title="E-mail the corresponding author ; Dagmar Heydeck
- 关键词：LOX ; lipoxygenase ; AA ; arachidonic acid ; EPA ; 5 ; 8 ; 11 ; 14 ; 17-eicosapentaenoic acid ; DHA ; 4 ; 7 ; 10 ; 13 ; 16 ; 19-docosahexaenoic acid ; 13S-H(p)ODE ; (13S ; 9Z ; 11E)-13-hydro(pero)xyoctadeca-9 ; 11-dienoic acid ; 15S-H(p)ETE ; (15S ; 5Z ; 8Z ; 11Z ; 13E)-15-hydro(pero)xyeicosa-5 ; 8 ; 11 ; 13-tetraenoic acid ; 12S-H(p)ETE ; (12S ; 5Z ; 8Z ; 10E ; 14Z)-12-hydro(pero)xyeicosa-5 ; 8 ; 10 ; 14-tetraenoic acid ; 11R-H(p)ETE ; (11R ; 5Z ; 8Z ; 12E ; 14Z)-11-hydro(pero)xyeicosa-5 ; 8 ; 12 ; 14-tetraenoic acid ; IL4(13) ; interleukin-4(13) ; DDX6 ; DEAD-box RNA helicase
- 刊名：Gene
- 出版年：2015
- 出版时间：15 November 2015
- 年：2015
- 卷：573
- 期：1
- 页码：1-32
- 全文大小：2687 K
文摘
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The human genome involves six lipoxygenase genes including ALOX15.
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ALOX15 specifically oxygenates phospholipids and biomembranes.
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ALOX15 exhibits a high degree of structural flexibility.
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90">ALOX15 plays a role in differentiation and in pathogenesis of various diseases.
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95">Evolutionary change in reaction specificity optimizes membrane oxygenase activity.