Overexpression of miR-183/-96/-182 triggers neuronal cell fate in Human Retinal Pigment Epithelial (hRPE) cells in culture

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• 作者：Maliheh Davari^a ; Zahra-Soheila Soheili^a ; ^{soheili@nigeb.ac.ir} ; ^{zahrasoheila@yahoo.com} ; Shahram Samiei^b ; Zohreh Sharifi^b ; Ehsan Ranaei Pirmardan^c
• 关键词：microRNAs ; miR-183 cluster ; hRPE cells ; Retinal neurons
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：29 January 2017
• 年：2017
• 卷：483
• 期：1
• 页码：745-751
• 全文大小：1149 K
• 卷排序：483

文摘

Ectopic overexpression of miR-183 cluster members was performed in hRPE cells. Retina-specific neuronal genes were induced in RPE cells expressing miR-183 cluster. Overexpression of miR-183 cluster genes could reprogram RPE cells to retinal neuron.