HIV-1 Tat disrupts blood-brain barrier integrity and increases phagocytic perivascular macrophages and microglia in the dorsal striatum of transgenic mice
HIV-1 Tat exposure disrupted the BBB, as evidenced by Na-F and HRP leakage into the brain. HIV-1 Tat exposure increased phagocytic macrophages/microglia within the caudate/putamen. HIV-1 Tat activated both perivascular and tissue-resident macrophages/microglia.