The impact of KIR2DS4 gene on clinical outcome after hematopoietic stem cell transplantation

详细信息    查看全文

• 作者：Marija Burek Kamenaric^a ; ^{mburek@kbc-zagreb.hr} ; Katarina Stingl Jankovic^a ; ^{katarinastingl@gmail.com} ; Zorana Grubic^a ; ^{zgrubic@kbc-zagreb.hr} ; Ranka Serventi Seiwerth^b ; Marija Maskalan^a ; ^{marija.maskalan@kbc-zagreb.hr} ; Damir Nemet^b ; Mirta Mikulic^c ; ^{mmikulic@kbc-zagreb.hr} ; Renata Zunec^a ; ^{rzunec@kbc-zagreb.hr}
• 关键词：AFND ; Allele Frequencies Net Database ; HSCT ; hematopoietic stem cell transplantation ; GVH ; graft versus host ; KIR ; killer cell immunoglobulin-like receptors ; GVHD ; graft versus host disease ; NK ; natural killer cell ; HLA ; human leukocyte antigen ; OS ; overall survival
• 刊名：Human Immunology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：78
• 期：2
• 页码：95-102
• 全文大小：898 K
• 卷排序：78

文摘

Killer cell immunoglobulin-like receptors (KIR) are a family of inhibitory/activating receptors expressed on NK cells. Interactions of KIR receptors with KIR ligands have been shown to modify hematopoietic stem cell transplantation (HSCT) outcome. The aim of this research was to determine the KIR2DS4 allele variants distribution among 111 patients with different hematological malignancy who underwent HSCT and their donors, and to evaluate KIR2DS4 alleles’ impact on HSCT outcome. The KIR gene frequency analysis showed a significantly higher incidence of full-length KIR2DS4 alleles among patients. The impact of KIR2DS4 alleles on transplantation outcomes revealed that donors’ full-length KIR2DS4 alleles is associated with lower overall survival rates, higher risk of GVHD and higher relapse incidence. The expression of full-length KIR2DS4 allele variants may contribute to a worse clinical outcome after HSCT. KIR typing for KIR2DS4 could be used as an additional criterion for selecting suitable donors in cases when more than one HLA identical donor is identified for a specific patient.