Outcomes of 75 patients over 12 years treated for acoustic neuromas with linear accelerator-based radiosurgery

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• 作者：Peng-Wei Hsu ; Cheng-Nen Chang ; Shih-Tseng Lee ; Yin-Cheng Huang ; Hsien-Chih Chen ; Chun-Chieh Wang ; Yung-Hsin Hsu ; Chen-Kan Tseng ; Yao-Liang Chen ; Kuo-Cheng Wei
• 关键词：Acoustic neuroma ; CT ; Gamma knife ; Image fusion ; LINAC ; MRI ; Radiosurgery
• 刊名：Journal of Clinical Neuroscience
• 出版年：2010
• 出版时间：May 2010
• 年：2010
• 卷：17
• 期：5
• 页码：556-560
• 全文大小：215 K

文摘

The aim of this study was to investigate the efficacy of linear accelerator (LINAC)-based radiosurgery in the treatment of acoustic neuromas. In this retrospective study, we enrolled 75 patients with non-neurofibromatosis type 2 acoustic neuromas who were followed-up for more than 5 years. The 75 patients were divided into 3 groups: patients with a newly diagnosed tumor; those with a residual tumor; and those with a recurrent tumor. The average follow-up period was 97.8 months. The overall tumor progression-free rate was 92 % , and corresponding rates among those with newly diagnosed tumors was 100 % , residual tumors was 84.4 % , and recurrent tumors was 92.8 % (p = 0.028). Lesion localization using CT scans correlated with a higher tendency for tumor progression than lesion localization using CT–MRI fusion images (15.6 % versus 2.4 % , respectively). Residual tumors treated with radiosurgery have a higher progression rate, and careful lesion localization using CT–MRI image fusion is required.