Successful treatment of a newborn with congenital hyperinsulinism having a novel heterozygous mutation in the ABCC8 gene using subtotal pancreatectomy

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• 作者：Chi-Feng Yen^a ; Chi-Yu Huang^a ; ^b ; Chon-In Chan^a ; Chiung-Hsing Hsu^a ; Nien-Lu Wang^c ; Tao-Yeuan Wang^d ; Chiung-Ling Lin^e ; Wei-Hsin Ting^a ; ^b ; ^{stczge@ms27.hinet.net}
• 关键词：18-fluoro L-3 ; 4-dihydroxyphenylalanine positron emission tomography ; ABCC8 ; Adenosine triphosphate-sensitive potassium Channel ; Congenital hyperinsulinism ; Sulfonylurea receptor 1
• 刊名：Tzu Chi Medical Journal
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：28
• 期：4
• 页码：162-165
• 全文大小：1024 K
• 卷排序：28

文摘

Congenital hyperinsulinism (CHI) is the most common cause of persistent hypoglycemia in newborns and infants. CHI is characterized by unregulated secretion of insulin from pancreatic β cells. Here, we reported the case of a large-for-gestational-age, full-term newborn that suffered from CHI and developed severe and persistent hypoglycemia at an early stage of life. The infant was nearly unresponsive to medical treatment, which included continuous intravenous glucagon infusion, oral diazoxide, and nifedipine. After medical treatment had failed, an 18-fluoro L-3,4-dihydroxyphenylalanine positron emission tomography scan of the patient showed a focal lesion at the neck of the pancreas. The patient received subtotal pancreatectomy, and shortly after the procedure, the patient's blood sugar returned to the normal range. The patient was confirmed to have a novel heterozygous mutation at position c.2475+1G>A of the ABCC8 gene. This is the first report of a focal form of CHI in a patient in Taiwan, which had preoperatively been confirmed using 18-fluoro L-3,4-dihydroxyphenylalanine positron emission tomography.