Concurrent delivery of carmustine, irinotecan, and cisplatin to the cerebral cavity using biodegradable nanofibers: In vitro and in vivo studies
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- 作者：Yuan-Yun Tsenga ; Yi-Chuan Wangb ; Chen-Hsing Suc ; Tao-Chieh Yangd ; Tzu-Min Changb ; Yi-Chuan Kaue ; Shih-Jung Liub ; shihjung@mail.cgu.edu.tw" class="auth_mail" title="E-mail the corresponding author
- 关键词：Nanofiber ; PLGA ; Glioblastoma multiforme (GBM) ; BCNU ; Cisplatin ; Irinotecan
- 刊名：Colloids and Surfaces B: Biointerfaces
- 出版年：2015
- 出版时间：1 October 2015
- 年：2015
- 卷：134
- 期：Complete
- 页码：254-261
- 全文大小：2191 K
文摘
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We developed biodegradable anti-cancer drug-eluting nanofibers.
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Nanofibers provided concurrent and sustained drug delivery to the cerebral cavity.
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Nanofibers released high concentrations of drugs for more than 8 weeks.
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Histological examination showed no inflammatory reactions of the brain tissues.