This work develops a composite system of reduced graphene oxide (rGO)–iron oxide nanoparticles (rGO–IONP) that can synergistically induce physical and chemical damage to methicil
lin-resistant
Staphylococcus aureus (MRSA) that are present in subcutaneous abscesses. rGO–IONP was synthesized by the chemical deposition of Fe
2 +/Fe
3 + ions on nanosheets of rGO in aqueous ammonia. The antibacterial efficacy of the as-prepared rGO–IONP was evaluated in a mouse model with MRSA-infected subcutaneous abscesses. Upon exposure to a near-infrared laser
in vitro, rGO–IONP synergistically generated localized heat and large amounts of hydroxyl radicals, which inactivated MRSA. The
in vivo results reveal that combined treatment with localized heat and oxidative stress that is caused by hydroxyl radicals accelerated the hea
ling of wounds associated with MRSA-infected abscesses. The above results demonstrate that an rGO–IONP nanocomposite system that can effectively inactivate multiple-drug-resistant bacteria in subcutaneous infections was successfully developed.
From the Clinical Editor
The emergence of methicillin-resistant S. aureus (MRSA) has posed a significant problem in the clinical setting. Thus, it is imperative to develop new treatment strategies against this. In this study, the authors described the use of reduced graphene oxide (rGO)-iron oxide nanoparticles (rGO-IONP) to induce heat and chemical damage to MRSA. This approach may provide a platform the design of other treatment modalities against multiple-drug-resistant bacteria.