Pu-erh tea attenuates smoking-induced foam cell formation through inhibition of the α9-nicotinic-acetylcholine receptor expression in monocytes: An ex vivo study
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- 作者：Li-Ching Chena ; b ; Ming-Yao Chena ; Shih-Hsin Tuc ; d ; e ; f ; Min-Hsiung Pang ; Chih-Yu Loh ; Chi-Tang Hoi ; Chih-Hsiung Wuc ; d ; j ; chwu@tmu.edu.tw" class="auth_mail" title="E-mail the corresponding author ; Yuan-Soon Hoc ; k ; l ; m ; hoyuansn@tmu.edu.tw" class="auth_mail" title="E-mail the corresponding author
- 关键词：C6 ; Coumarin VI ; ICAM-1 ; intercellular adhesion molecule-1 ; IL-6 ; interleukin-6 ; EGCG ; (-)-epigallocatechin gallate ; nAchRs ; nicotinic acetylcholine receptors ; ox-LDL ; oxidized low-density lipoprotein ; PBMC ; peripheral blood mononuclear cells ; VCAM-1 ; vascular cell adhesion molecule-1 ; WBC ; white blood cells
- 刊名：Journal of Functional Foods
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：22
- 期：Complete
- 页码：132-144
- 全文大小：3766 K
文摘
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Nearly 90% of the α9-nAchR protein was exclusively expressed in monocytes.
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Nicotine-induced foam-cell formation was significantly observed in monocytes from heavy smokers.
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Tea consumption downregulated the monocytic α9-nAchR expression which that causes resist nicotine-induced foam cell formation.
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Tea-drinking effectively attenuates the initial step (foam-cell formation) of smoking-induced atherosclerosis in circulating monocytes.