Structural characterization of low molecular weight polysaccharide from Astragalus membranaceus and its immunologic enhancement in recombinant protein vaccine against systemic candidiasis
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- 作者：Fan Yang ; Chunyu Xiao ; Jing Qu ; Guiyun Wang ; wanggy737@nenu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：LMw-ASP ; low molecular weight polysaccharide isolated from the root of Astragalus membranaceus ; HSP90 ; heat shock protein 90 ; rP-HSP90C ; a recombinant protein containing epitope C (LKVIRK) from HSP90 of C. albicans
- 刊名：Carbohydrate Polymers
- 出版年：2016
- 出版时间：10 July 2016
- 年：2016
- 卷：145
- 期：Complete
- 页码：48-55
- 全文大小：1138 K
文摘
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Structure of LMw-ASP is analyzed.
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LMW-ASP enhances significantly specific antibody titers IgG, IgG1and IgG2b.
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LMW-ASP promotes significantly production of IL-2, IL-4, IL-10, IL-12 in sera of mice.
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LMW-ASP reduces significantly the numbers of CFU in the kidneys of mice.
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LMw-ASP may be an adjuvant which greatly improved Th1 and Th2 responses in recombinant protein rP-HSP90C.