Proliferating BMSCs expresses relatively higher cyclins B1 and D2 than HSPCs.
HDACs are differentially expressed in BMSCs and HSPCs.
HDAC inhibition potentiates BMSC and HSPC proliferation by increasing AcH3 and AcH4 and cyclins B1 and D2.
TSA decrease binding of HDAC2 and 3 on cyclins B1 and D2 promoter.