Dedifferentiation of atrial cardiomyocytes in cardiac valve disease: unrelated to atrial fibrillation

详细信息    查看全文

• 作者：Mien-Cheng Chen ; Jen-Ping Chang ; Shun-Chen Huang ; Hsueh-Wen Chang ; Chien-Jen Chen ; Cheng-Hsu Yang ; Wen-Hao Liu
• 关键词：Atrial fibrillation ; Atrium ; Cardiomyocytes ; Dedifferentiation ; Cardiac valve disease
• 刊名：Cardiovascular Pathology
• 出版年：2008
• 出版时间：May-June 2008
• 年：2008
• 卷：17
• 期：3
• 页码：156-165
• 全文大小：1677 K

文摘

Valvular heart disease has become an important public health concern. The increased wall stress and underlying disease entity associated with mitral valve disease provide unfavorable circumstances for atrial cardiomyocytes. The expression of the -smooth muscle actin isoform is considered characteristic of cardiomyocyte dedifferentiation (embryonic cardiomyocyte), and cardiomyocyte dedifferentiation may indicate an adaptive state, enabling cardiomyocytes to survive despite unfavorable circumstances.